When you see this, it's using one of the program's/game's base address and adding offsets from that address, for example "Game.exe"+10545612 which would point to another address. I believe Fleep goes over how to get the base address of the game in one of his tutorials. It's pretty straightforward, something along the lines of MyProcess.MainModule.BaseAddress.ToInt32() + 0x10545612; (C#) where MyProcess = GameName. This is all theoretical of course, copying it won't be functional whatsoever.
Do the tutorials, this is really basic
https://guidedhacking.com/starthere