So if its a 2D game u see everything from top. Get your screen position by moving cursor on your char and caling GetCursorPos. Then do the same for one enemy. Count distance with pythagoran (i dont know english version but u knwo what i mean). Then count the distance with ingame coords and count proportion. Thats all, this is just a basic math, so you know the screen distance using ingame coords. Then get angle and ur done
Btw game name?